Neutral Lipid Delivery Technology Platform

Bio-Path Holdings

Development of antisense drugs has been limited by the lack of a suitable method to deliver high concentration of these drugs to the diseased cells.

Bio-Path's delivery technology is different from most other lipid-based delivery technologies, which use positively charged lipids to form complexes between the lipids and the molecules of interest. Bio-Path's neutral lipids form structures similar to the cellular membrane, therefore allowing the antisense drug to be incorporated within the lipid layers and be delivered to the diseased cells with high uptake into the cell.

The major benefit of Bio-Path's neutral lipid technology compared to the cationic lipid technology is that there has been no evidence of toxicity with Bio-Path's technology, while cationic lipid technology has known toxic side effects that have limited its development into viable treatments for cancer.


Conclusion

Bio-Path’s neutral lipid delivery technology provides systemic distribution of nucleic acid antisense drugs throughout the human body by simple intravenous infusion.


Relevance/Opportunity

Bio-Path seeks to apply its proprietary technology to new protein targets in cancer and in other disease indications. The Company is interested in pursuing a wide-ranging, proactive licensing program to include co-development of a specific liposomal antisense drug candidate; sub-license the delivery template for outside development of one or more liposomal antisense drug candidates; or out-license a partially developed drug for final development and marketing.


Abstract Details

Pipeline Status: Preclinical
Platform: Platform Technology
Published Date: 30 Sep 2015
Original Date: 30 Sep 2015

Contact Details

Contact Person: Peter Nielsen
Address:
Bio-Path Holdings
United States
Telephone: 832-742-1357
Fax:
Web URL: http://www.biopathholdings.com/
E-mail:
Therapeutic Areas:
Drug Delivery
Technical Applications